GAR1

Across TCGA patient cohorts, GAR1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAR1-associated genes across cancer lineages are FoxM1, INPP4B, and JNK_pT183_Y185. Each is linked with GAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAR1-to-partner and partner-to-GAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GAR1-low versus GAR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAR1→partner) and Y-score (partner→GAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.260	+2.222	.018	.011	3	1
UCEC	INPP4B →	-0.294	-3.169	.032	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-1.687	.026	.044	3	1
UCEC	JNK2 →	+0.236	+1.700	.005	.044	3	1
UCEC	MEK1 →	+0.410	+2.222	.008	.011	3	1
UCEC	p62 Lck ligand →	+0.341	+2.179	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by GAR1 expression — UCEC

Explore this box plot interactively →