GAPDHS

Across TCGA cell cohorts, GAPDHS mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAPDHS-associated genes across cancer lineages are MYOD1, SSMEM1, and OR1L6. Each is linked with GAPDHS in more than 1 cancer types. Because this analysis shows association rather than direction, both GAPDHS-to-partner and partner-to-GAPDHS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by GAPDHS-low versus GAPDHS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAPDHS→partner) and Y-score (partner→GAPDHS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYOD1 →	+0.014	+3.684	<.001	.006	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.028	+4.614	<.001	.002	3	1
BLOOD_Leukemia	NPY2R →	+0.094	+4.539	<.001	.007	3	1
LARGE_INTESTINE	COL25A1 →	+0.057	+4.070	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MYOD1 by GAPDHS expression — LARGE_INTESTINE

Explore this box plot interactively →