Across TCGA pan-cancer cohorts, GAPDHP49 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GAPDHP49’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where GAPDHP49 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAPDHP49 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
STAD, KICH, and THCA are the cancer types where GAPDHP49 tumor–normal differential expression is most reproducible.