GAP43

Across TCGA pan-cancer cohorts, GAP43 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GAP43 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GAP43 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GAP43 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where GAP43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.664	0.908	.005	18	view →
HNSC	OS	Tertile	IV	0.553	0.841	.031	5	view →
LUAD	DFS	Tertile	All	0.630	1.000	.029	5	view →
UCEC	OS	Median	II,III,IV	0.428	0.855	.027	4	view →
PDAC	OS	Median	All	0.949	0.702	.024	3	view →
GBM	OS	Median	All	0.607	0.916	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GAP43–LSCC (OS)

Open the LSCC breakdown →