GAP43

Across TCGA pan-cancer cohorts, GAP43 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GAP43’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GAP43 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GAP43 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where GAP43 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAP43 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.724	<.001	12	view →
HNSC	Male	II,III,IV	−0.795	<.001	8	view →
CCRCC	All	All	−0.784	.001	6	view →
LSCC	Male	All	+0.731	<.001	6	view →
LUAD	Male	All	+0.721	<.001	5	view →
PDAC	Male	IV	−1.405	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GAP43–COAD

Open the COAD breakdown →