GAP43

Across TCGA patient cohorts, GAP43 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAP43-associated genes across cancer lineages are PDCD4, C-Raf, and Ku80. Each is linked with GAP43 in more than 2 cancer types. Because this analysis shows association rather than direction, both GAP43-to-partner and partner-to-GAP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by GAP43-low versus GAP43-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAP43→partner) and Y-score (partner→GAP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PDCD4 →	-0.523	-2.972	.017	.036	3	3
UCEC	C-Raf →	+0.150	+2.115	.005	.017	3	3
UCEC	Ku80 →	+0.251	+3.335	.004	.005	3	2
UCEC	MEK1 →	+0.473	+3.321	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.326	+3.584	.001	.002	3	2
UCEC	Cyclin-B1 →	+0.645	+2.700	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PDCD4 by GAP43 expression — LUSC

Explore this box plot interactively →