Across TCGA patient cohorts, GANC mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GANC-associated genes across cancer lineages are mTOR_pS2448, FoxM1, and Caspase-7-cleavedD198. Each is linked with GANC in more than 3 cancer types. Because this analysis shows association rather than direction, both GANC-to-partner and partner-to-GANC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GANC→partner) and Y-score (partner→GANC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.149	-2.302	.002	<.001	3	4
UCEC	FoxM1 →	+0.199	+1.716	.017	.003	3	3
UCEC	Caspase-7-cleavedD198 →	+0.683	+2.267	<.001	<.001	3	3
UCEC	eIF4E →	+0.174	+2.000	.011	.009	3	2
UCEC	FOXO3a_pS318_S321 →	-0.088	-1.430	.029	.022	3	2
UCEC	MSH2 →	-0.186	-1.674	.013	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

GANC survival (RNA) · tumor vs normal (RNA) · all GANC data types