GANAB

Across TCGA pan-cancer cohorts, GANAB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GANAB data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GANAB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GANAB expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where GANAB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.202	0.985	.007	23	view →
LSCC	DFS	Median	II,III,IV	0.530	0.858	.006	9	view →
PDAC	OS	Median	All	0.781	0.904	.019	6	view →
LUAD	DFS	Median	II,III,IV	0.871	0.320	.021	6	view →
HNSC	DFS	Median	III,IV	0.895	0.361	.007	6	view →
GBM	DFS	Quartile	All	0.638	0.874	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GANAB–CCRCC (OS)

Open the CCRCC breakdown →