GANAB

Across TCGA patient cohorts, GANAB mutation is significantly associated with the RNA expression of many other genes, with 4,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GANAB-associated genes across cancer lineages are FAM98A, CHEK1, and OBI1. Each is linked with GANAB in more than 3 cancer types. Because this analysis shows association rather than direction, both GANAB-to-partner and partner-to-GANAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM98A grouped by GANAB-low versus GANAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GANAB→partner) and Y-score (partner→GANAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM98A →	+0.267	+1.950	.007	.002	3	4
UCEC	CHEK1 →	+0.648	+3.191	<.001	<.001	3	3
UCEC	OBI1 →	+0.453	+1.947	<.001	<.001	3	3
UCEC	C18orf25 →	+0.371	+3.010	.002	<.001	3	3
UCEC	ZUP1 →	+0.517	+2.254	<.001	<.001	3	3
UCEC	NUS1 →	+0.415	+3.021	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,029 associations by consensus.

FAM98A by GANAB expression — UCEC

Explore this box plot interactively →