GANAB

Across TCGA patient cohorts, GANAB mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GANAB-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and C-Raf. Each is linked with GANAB in more than 3 cancer types. Because this analysis shows association rather than direction, both GANAB-to-partner and partner-to-GANAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GANAB-low versus GANAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GANAB→partner) and Y-score (partner→GANAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.519	+2.107	.007	.002	3	4
UCEC	eEF2 →	+0.248	+2.321	.035	.033	3	2
UCEC	C-Raf →	+0.165	+2.415	<.001	.003	3	2
UCEC	Di-Ras3 →	-0.174	-3.986	<.001	<.001	3	2
CESC	Chk1 →	+0.303	+2.833	.043	.031	3	1
UCEC	14-3-3_beta →	-0.108	-3.880	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by GANAB expression — UCEC

Explore this box plot interactively →