GANAB

Across TCGA cell cohorts, GANAB mutation is significantly associated with the RNA expression of many other genes, with 316 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GANAB-associated genes across cancer lineages are VWC2L, TSPYL6, and IFNA5. Each is linked with GANAB in more than 1 cancer types. Because this analysis shows association rather than direction, both GANAB-to-partner and partner-to-GANAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by GANAB-low versus GANAB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GANAB→partner) and Y-score (partner→GANAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.006	+2.924	.003	.001	3	2
BLOOD_Leukemia	TSPYL6 →	+0.374	+2.989	<.001	.002	3	2
LUNG_SCLC	IFNA5 →	+0.035	+2.830	.003	.009	3	1
LUNG_SCLC	PLET1 →	+0.034	+3.129	<.001	.003	3	1
LUNG_SCLC	OR5M11 →	+0.055	+3.099	.002	.003	3	1
URINARY_TRACT	SIGLEC5 →	+1.041	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 316 associations by consensus.

VWC2L by GANAB expression — BLOOD_Leukemia

Explore this box plot interactively →