GAN

Across TCGA patient cohorts, GAN RNA expression is significantly associated with the protein abundance of many other proteins, with 19,958 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GAN-associated proteins across cancer lineages are GPRIN3, SAMHD1_S33, and SASH3. Each is linked with GAN in more than 5 cancer types. Because this analysis shows association rather than direction, both GAN-to-partner and partner-to-GAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GAN versus GPRIN3 in LSCC, with a Pearson correlation of -0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GAN→partner) and Y-score (partner→GAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPRIN3 →	-0.425	-0.789	<.001	<.001	3	6
GBM	SAMHD1_S33 →	-0.517	-0.481	<.001	<.001	3	5
GBM	SASH3 →	-0.503	-0.635	<.001	<.001	3	5
LSCC	BIN2_T478 →	-0.828	-0.969	<.001	<.001	3	5
GBM	DEF6 →	-0.662	-0.718	<.001	<.001	3	5
GBM	DOCK2_S1592 →	-0.539	-0.465	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,958 associations by consensus.

GAN vs GPRIN3 — LSCC

Explore this scatter interactively →