GAN

Across TCGA patient cohorts, GAN protein abundance is significantly associated with the RNA expression of many other genes, with 14,248 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GAN-associated genes across cancer lineages are CRYAB, KRT16, and KRT6A. Each is linked with GAN in more than 4 cancer types. Because this analysis shows association rather than direction, both GAN-to-partner and partner-to-GAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GAN versus CRYAB in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAN→partner) and Y-score (partner→GAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRYAB →	+1.914	+0.404	<.001	.001	3	5
HNSC	KRT16 →	+2.121	+0.371	<.001	.001	3	5
LSCC	KRT6A →	+3.768	+0.656	<.001	<.001	3	5
COAD	LINC00513 →	-0.754	-0.294	.001	<.001	3	5
BRCA	PKP1 →	+1.618	+0.338	<.001	.002	3	5
LSCC	SPRR1B →	+3.672	+0.617	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,248 associations by consensus.

GAN vs CRYAB — BRCA

Explore this scatter interactively →