GAN

Across TCGA patient cohorts, GAN mutation is significantly associated with the RNA expression of many other genes, with 2,808 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAN-associated genes across cancer lineages are TRDV1, RNU6-296P, and RNU6-1274P. Each is linked with GAN in more than 2 cancer types. Because this analysis shows association rather than direction, both GAN-to-partner and partner-to-GAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDV1 grouped by GAN-low versus GAN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAN→partner) and Y-score (partner→GAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRDV1 →	+1.110	+3.584	<.001	.002	3	3
LUAD	RNU6-296P →	+0.433	+4.612	<.001	.006	3	3
READ	RNU6-1274P →	+0.782	+5.925	<.001	.002	3	2
READ	HSPA8P17 →	+0.109	+6.681	<.001	<.001	3	2
READ	LINC01895 →	+0.221	+5.925	<.001	.002	3	2
SKCM	RNU6-625P →	+0.198	+4.328	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,808 associations by consensus.

TRDV1 by GAN expression — COAD

Explore this box plot interactively →