GAN

Across TCGA cell cohorts, GAN mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAN-associated genes across cancer lineages are HTR1A, SLC39A6, and RSPH10B. Each is linked with GAN in more than 1 cancer types. Because this analysis shows association rather than direction, both GAN-to-partner and partner-to-GAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1A grouped by GAN-low versus GAN-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAN→partner) and Y-score (partner→GAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HTR1A →	+0.030	+5.087	<.001	.004	3	1
LARGE_INTESTINE	SLC39A6 →	+0.991	+3.064	.004	.009	3	1
LARGE_INTESTINE	RSPH10B →	+0.358	+3.215	<.001	.009	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.093	+3.845	<.001	<.001	3	1
LARGE_INTESTINE	BLOC1S2 →	+0.594	+3.302	.005	.008	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.171	+2.444	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

HTR1A by GAN expression — URINARY_TRACT

Explore this box plot interactively →