GALR2

Across TCGA cell cohorts, GALR2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GALR2-associated genes across cancer lineages are SCN2A, ARL13A, and ODF3. Each is linked with GALR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GALR2-to-partner and partner-to-GALR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN2A grouped by GALR2-low versus GALR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALR2→partner) and Y-score (partner→GALR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCN2A →	+0.481	+3.658	<.001	.003	3	1
LARGE_INTESTINE	ARL13A →	+0.060	+3.369	.009	.007	3	1
LARGE_INTESTINE	ODF3 →	+0.052	+3.836	<.001	.003	3	1
LARGE_INTESTINE	CT45A8 →	+0.020	+3.115	.001	.004	3	1
LARGE_INTESTINE	TRH →	+0.109	+2.830	<.001	.009	1	1
LARGE_INTESTINE	RAB44 →	+0.080	+3.520	.002	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SCN2A by GALR2 expression — LARGE_INTESTINE

Explore this box plot interactively →