Across TCGA pan-cancer cohorts, GALP RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of GALP’s most consistent transcriptional readouts.
The strongest signal is observed in cholangiocarcinoma (CHOL), where GALP RNA is repressed in tumor relative to normal tissue. In most cancer types GALP is over-expressed in tumor, although a few such as CHOL show the opposite, repressed pattern.
CHOL, UCEC, and LUAD are the cancer types where GALP tumor–normal differential expression is most reproducible.