GALNT6

Across TCGA patient cohorts, GALNT6 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALNT6-associated genes across cancer lineages are 4E-BP1, GAPDH, and ACC1. Each is linked with GALNT6 in more than 3 cancer types. Because this analysis shows association rather than direction, both GALNT6-to-partner and partner-to-GALNT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GALNT6-low versus GALNT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALNT6→partner) and Y-score (partner→GALNT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.424	+3.730	<.001	<.001	2	4
UCEC	GAPDH →	+0.551	+2.459	.008	.018	3	2
UCEC	ACC1 →	+0.330	+1.750	.020	.049	3	2
UCEC	Ku80 →	+0.322	+2.515	<.001	.001	3	2
UCEC	MSH2 →	-0.190	-3.143	.036	.018	3	2
UCEC	p62 Lck ligand →	+0.483	+2.710	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

4E-BP1 by GALNT6 expression — UCEC

Explore this box plot interactively →