GALNT3

Across TCGA cell cohorts, GALNT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,032 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GALNT3-associated GO terms across cancer lineages are Regulation of blood-brain barrier permeability, Maintenance of blood-brain barrier, and Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity. Each is linked with GALNT3 in more than 11 cancer types. Because this analysis shows association rather than direction, both GALNT3-to-partner and partner-to-GALNT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of blood-brain barrier permeability grouped by GALNT3-low versus GALNT3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GALNT3→partner) and Y-score (partner→GALNT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of blood-brain barrier permeability →	+0.289	+2.902	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.187	+2.620	<.001	<.001	3	12
LARGE_INTESTINE	Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity →	+0.162	+1.822	<.001	<.001	3	12
STOMACH	Intracellular sodium ion homeostasis →	+0.296	+2.746	<.001	<.001	3	12
STOMACH	Regulation of ventricular cardiac muscle cell action potential →	+0.256	+3.110	<.001	<.001	3	12
OESOPHAGUS	Positive regulation of sodium ion transport →	+0.234	+2.566	<.001	.007	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,032 associations by consensus.

Regulation of blood-brain barrier permeability by GALNT3 expression — STOMACH

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