GALNT16

Across TCGA pan-cancer cohorts, GALNT16 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated GALNT16 data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GALNT16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GALNT16 expression acts as an unfavorable survival marker, although some lineages such as KIRP and PAAD show a favorable association.

BLCA, KIRP, and PAAD are the cancer types where GALNT16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.319	0.572	<.001	111	view →
KIRP	OS	Median	All	0.978	0.882	<.001	94	view →
PAAD	OS	Tertile	All	0.761	0.518	<.001	63	view →
BRCA	OS	Median	III,IV	0.644	0.430	<.001	61	view →
KICH	DFS	Tertile	III,IV	1.000	0.272	.005	55	view →
HNSC	DFS	Tertile	II,III,IV	0.746	0.609	.004	52	view →
LGG	DFS	Median	All	0.509	0.314	<.001	43	view →
UVM	DFS	Quartile	All	0.635	0.933	.007	31	view →
OV	DFS	Quartile	III,IV	0.596	0.474	.013	24	view →
MESO	OS	Tertile	III,IV	0.554	0.754	.003	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GALNT16–BLCA (OS)

Open the BLCA breakdown →