GALNT15

Across TCGA patient cohorts, GALNT15 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALNT15-associated genes across cancer lineages are eIF4E, ERK2, and MEK1. Each is linked with GALNT15 in more than 1 cancer types. Because this analysis shows association rather than direction, both GALNT15-to-partner and partner-to-GALNT15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GALNT15-low versus GALNT15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALNT15→partner) and Y-score (partner→GALNT15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.220	+4.013	<.001	<.001	3	2
SKCM	ERK2 →	+0.215	+2.459	.015	.018	3	2
UCEC	MEK1 →	+0.387	+2.392	<.001	<.001	3	2
UCEC	MSH2 →	-0.194	-1.558	.007	.032	3	2
UCEC	STAT3_pY705 →	-0.387	-2.060	<.001	.001	3	2
UCEC	Tuberin →	+0.317	+1.906	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

eIF4E by GALNT15 expression — UCEC

Explore this box plot interactively →