GALNS

Across TCGA patient cohorts, GALNS mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALNS-associated genes across cancer lineages are EGFR_pY1068, ERK2, and JNK2. Each is linked with GALNS in more than 1 cancer types. Because this analysis shows association rather than direction, both GALNS-to-partner and partner-to-GALNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GALNS-low versus GALNS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALNS→partner) and Y-score (partner→GALNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-2.584	.008	.010	3	1
UCEC	ERK2 →	+0.228	+3.459	.004	.005	3	1
UCEC	JNK2 →	+0.262	+1.807	.001	.027	3	1
UCEC	MEK1 →	+0.502	+3.584	<.001	.002	3	1
UCEC	MSH2 →	-0.333	-3.449	<.001	.005	3	1
UCEC	MSH6 →	-0.408	-2.449	.002	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by GALNS expression — UCEC

Explore this box plot interactively →