GALNS

Across TCGA cell cohorts, GALNS mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GALNS-associated genes across cancer lineages are EPYC, LGI1, and LRIT1. Each is linked with GALNS in more than 1 cancer types. Because this analysis shows association rather than direction, both GALNS-to-partner and partner-to-GALNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPYC grouped by GALNS-low versus GALNS-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALNS→partner) and Y-score (partner→GALNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EPYC →	+0.685	+4.044	<.001	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.112	+6.124	<.001	<.001	3	1
BLOOD_Leukemia	LRIT1 →	+0.041	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	DPRX →	+0.143	+5.060	<.001	.001	3	1
BLOOD_Leukemia	LRRC10 →	+0.329	+4.129	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EPYC by GALNS expression — LUNG_SCLC

Explore this box plot interactively →