GALK2

Across TCGA patient cohorts, GALK2 mutation is significantly associated with the RNA expression of many other genes, with 1,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALK2-associated genes across cancer lineages are RN7SL25P, ZIC3, and ZFYVE19. Each is linked with GALK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GALK2-to-partner and partner-to-GALK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL25P grouped by GALK2-low versus GALK2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALK2→partner) and Y-score (partner→GALK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL25P →	+0.308	+5.925	<.001	.002	3	3
READ	ZIC3 →	+0.035	+5.653	<.001	.003	3	2
UCEC	ZFYVE19 →	+0.353	+2.136	.006	.009	3	2
UCEC	SPATA5L1 →	+0.425	+2.673	.003	<.001	3	2
UCEC	BNIP3 →	+0.656	+2.662	.008	<.001	3	2
UCEC	JMJD6 →	+0.654	+3.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,908 associations by consensus.

RN7SL25P by GALK2 expression — READ

Explore this box plot interactively →