GALE

Across TCGA pan-cancer cohorts, GALE mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GALE data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GALE mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GALE expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where GALE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	17	view →
LUAD	OS	Median	III,IV	0.663	1.000	.007	13	view →
PDAC	OS	Median	IV	0.381	0.951	.006	13	view →
UCEC	DFS	Tertile	All	0.969	0.807	.005	10	view →
CCRCC	DFS	Median	III,IV	0.958	0.769	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GALE–HNSC (OS)

Open the HNSC breakdown →