GALE

Across TCGA pan-cancer cohorts, GALE mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GALE’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where GALE mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GALE is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

PDAC, LUAD, and LSCC are the cancer types where GALE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GALE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	III,IV	+0.915	<.001	9	view →
LUAD	Female	II,III,IV	+0.526	<.001	9	view →
LSCC	Male	II,III,IV	−0.466	<.001	8	view →
HNSC	Male	All	−0.482	<.001	6	view →
CCRCC	All	All	−0.146	.002	5	view →
COAD	All	All	+0.111	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GALE–PDAC

Open the PDAC breakdown →