GALE

Across TCGA patient cohorts, GALE protein abundance is significantly associated with the RNA expression of many other genes, with 21,429 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GALE-associated genes across cancer lineages are PAFAH2, UBXN10, and LYPLA2. Each is linked with GALE in more than 7 cancer types. Because this analysis shows association rather than direction, both GALE-to-partner and partner-to-GALE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GALE versus PAFAH2 in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALE→partner) and Y-score (partner→GALE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAFAH2 →	+0.825	+0.490	<.001	<.001	3	8
CCRCC	UBXN10 →	+1.248	+0.473	<.001	<.001	3	8
LUAD	LYPLA2 →	+0.468	+0.448	<.001	<.001	3	7
UCEC	HMGCL →	+0.490	+0.266	<.001	.002	3	7
CCRCC	SERINC2 →	+1.280	+0.416	<.001	<.001	3	7
BRCA	AGR2 →	+3.742	+0.540	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,429 associations by consensus.

GALE vs PAFAH2 — UCEC

Explore this scatter interactively →