Across TCGA pan-cancer cohorts, GAGE2A RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of GAGE2A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GAGE2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAGE2A is over-expressed in tumor.

HNSC, LIHC, and LUSC are the cancer types where GAGE2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAGE2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.423	.027	4	view →
LIHC	All	All	+0.280	.008	2	view →
LUSC	All	All	+0.437	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: GAGE2A RNA expression & survival · all GAGE2A data types