GAD1

Across TCGA pan-cancer cohorts, GAD1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GAD1 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GAD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GAD1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, COAD, and PCPG are the cancer types where GAD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.156	0.657	.027	12	view →
COAD	OS	Median	III,IV	0.208	0.791	.008	9	view →
PCPG	DFS	Median	All	0.229	0.822	.024	6	view →
BLCA	DFS	Median	IV	0.090	0.476	.011	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	0.785	0.552	.019	4	view →
LUSC	OS	Median	II,III,IV	0.259	0.732	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GAD1–CESC (OS)

Open the CESC breakdown →