GAD1

Across TCGA patient cohorts, GAD1 mutation is significantly associated with the RNA expression of many other genes, with 3,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAD1-associated genes across cancer lineages are INCENP, RNU6-622P, and GPAA1P1. Each is linked with GAD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAD1-to-partner and partner-to-GAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INCENP grouped by GAD1-low versus GAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD1→partner) and Y-score (partner→GAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INCENP →	+0.575	+2.446	.001	.001	3	4
BRCA	RNU6-622P →	+0.268	+8.471	<.001	.005	3	3
LUAD	GPAA1P1 →	+0.023	+4.584	<.001	.005	3	3
UCEC	SSRP1 →	+0.401	+1.939	.007	.009	3	3
UCEC	HIRIP3 →	+0.449	+2.765	<.001	<.001	3	3
UCEC	CWC27 →	+0.426	+2.287	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,120 associations by consensus.

INCENP by GAD1 expression — UCEC

Explore this box plot interactively →