GAD1

Across TCGA patient cohorts, GAD1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAD1-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and MEK1. Each is linked with GAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GAD1-to-partner and partner-to-GAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GAD1-low versus GAD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD1→partner) and Y-score (partner→GAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.441	+3.330	<.001	.005	3	3
COAD	INPP4B →	-0.495	-3.000	.004	.034	3	2
UCEC	MEK1 →	+0.341	+2.000	.007	.009	3	2
UCEC	S6_pS240_S244 →	+0.576	+3.713	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.229	-1.906	.008	.015	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-2.321	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by GAD1 expression — COAD

Explore this box plot interactively →