GAD1

Across TCGA cell cohorts, GAD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,926 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GAD1-associated GO terms across cancer lineages are L-glutamate catabolic process, Export across plasma membrane, and Succinate metabolic process. Each is linked with GAD1 in more than 13 cancer types. Because this analysis shows association rather than direction, both GAD1-to-partner and partner-to-GAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-glutamate catabolic process grouped by GAD1-low versus GAD1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD1→partner) and Y-score (partner→GAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	L-glutamate catabolic process →	-0.275	-1.226	<.001	.005	2	14
BREAST	Export across plasma membrane →	-0.095	-1.345	<.001	.001	3	8
PANCREAS	Succinate metabolic process →	-0.162	-1.516	<.001	<.001	3	7
LUNG_SCLC	Regulation of intracellular transport →	+0.043	+1.718	<.001	<.001	3	7
BONE	Mitochondrial electron transport, cytochrome c to oxygen →	+0.067	+1.170	.002	.005	3	7
BLOOD_Leukemia	Regulation of stress-activated MAPK cascade →	+0.049	+1.094	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,926 associations by consensus.

L-glutamate catabolic process by GAD1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →