GAD1

Across TCGA cell cohorts, GAD1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GAD1-associated genes across cancer lineages are TACR3, PRND, and RXFP3. Each is linked with GAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAD1-to-partner and partner-to-GAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TACR3 grouped by GAD1-low versus GAD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD1→partner) and Y-score (partner→GAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TACR3 →	+0.028	+3.475	<.001	.006	3	1
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	1
BLOOD_Leukemia	RXFP3 →	+0.008	+3.289	.002	.009	3	1
BLOOD_Leukemia	OR56A4 →	+0.007	+3.289	<.001	.009	3	1
BLOOD_Leukemia	TEX43 →	+0.070	+3.969	<.001	.009	3	1
BLOOD_Leukemia	CCT8L2 →	+0.012	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TACR3 by GAD1 expression — BLOOD_Leukemia

Explore this box plot interactively →