Across TCGA pan-cancer cohorts, GACAT1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of GACAT1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GACAT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GACAT1 is over-expressed in tumor.
HNSC are the cancer types where GACAT1 tumor–normal differential expression is most reproducible.