GABRR2

Across TCGA patient cohorts, GABRR2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRR2-associated genes across cancer lineages are Ku80, Shc_pY317, and Smad3. Each is linked with GABRR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GABRR2-to-partner and partner-to-GABRR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GABRR2-low versus GABRR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRR2→partner) and Y-score (partner→GABRR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.347	+2.235	<.001	.006	3	2
UCEC	Shc_pY317 →	-0.317	-3.807	<.001	<.001	3	2
UCEC	Smad3 →	+0.128	+2.999	.046	.035	3	2
UCEC	STAT3_pY705 →	-0.375	-1.990	<.001	.030	3	2
UCEC	C-Raf →	+0.265	+2.000	<.001	.030	3	2
UCEC	eEF2 →	+0.482	+3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Ku80 by GABRR2 expression — UCEC

Explore this box plot interactively →