GABRR1

Across TCGA patient cohorts, GABRR1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRR1-associated genes across cancer lineages are TFRC, MSH2, and Notch1. Each is linked with GABRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRR1-to-partner and partner-to-GABRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by GABRR1-low versus GABRR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRR1→partner) and Y-score (partner→GABRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+1.133	+3.169	<.001	.018	3	2
UCEC	MSH2 →	-0.320	-2.973	.001	.035	3	1
UCEC	Notch1 →	+0.152	+3.179	.013	.010	3	1
UCEC	p62 Lck ligand →	+0.388	+3.169	.006	.018	3	1
UCEC	Tuberin →	+0.276	+2.179	.019	.034	3	1
UCEC	XBP1 →	-0.192	-1.861	.001	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TFRC by GABRR1 expression — SKCM

Explore this box plot interactively →