GABRR1

Across TCGA cell cohorts, GABRR1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRR1-associated genes across cancer lineages are CCR6, KRTAP21-2, and KRTAP4-2. Each is linked with GABRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRR1-to-partner and partner-to-GABRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR6 grouped by GABRR1-low versus GABRR1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRR1→partner) and Y-score (partner→GABRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCR6 →	+0.192	+3.978	<.001	.005	3	1
CNS	KRTAP21-2 →	+0.214	+3.643	<.001	.007	3	1
CNS	KRTAP4-2 →	+0.103	+4.169	<.001	.008	3	1
BLOOD_Lymphoma	SMCP →	+0.034	+4.867	<.001	.009	3	1
LARGE_INTESTINE	SERAC1 →	+0.650	+3.067	.006	.009	3	1
LARGE_INTESTINE	RASGEF1C →	+0.205	+3.321	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CCR6 by GABRR1 expression — CNS

Explore this box plot interactively →