Across TCGA pan-cancer cohorts, GABRG3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GABRG3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GABRG3 RNA is repressed in tumor relative to normal tissue. In most cancer types GABRG3 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.
KIRC, COAD, and THCA are the cancer types where GABRG3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABRG3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.