GABRG2

Across TCGA patient cohorts, GABRG2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRG2-associated genes across cancer lineages are FoxM1, Annexin-1, and Cyclin-B1. Each is linked with GABRG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GABRG2-to-partner and partner-to-GABRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GABRG2-low versus GABRG2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRG2→partner) and Y-score (partner→GABRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FoxM1 →	+0.292	+2.838	.032	.033	3	4
SKCM	Annexin-1 →	-0.457	-1.807	.015	.026	2	4
UCEC	Cyclin-B1 →	+0.592	+2.584	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.414	-1.334	.001	.006	3	3
UCEC	Cyclin-E2 →	+0.117	+1.169	.016	.017	3	3
LUSC	JNK2 →	+0.234	+2.727	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

FoxM1 by GABRG2 expression — STAD

Explore this box plot interactively →