GABRG2

Across TCGA cell cohorts, GABRG2 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GABRG2-associated genes across cancer lineages are LORICRIN, XKR5, and PSG8. Each is linked with GABRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRG2-to-partner and partner-to-GABRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LORICRIN grouped by GABRG2-low versus GABRG2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRG2→partner) and Y-score (partner→GABRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LORICRIN →	+0.033	+3.716	<.001	.005	3	1
BLOOD_Myeloma	XKR5 →	+0.049	+3.285	.006	.009	3	1
LUNG_SCLC	PSG8 →	+0.078	+3.898	.007	.005	3	1
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	LYZL2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	LCE3D →	+0.068	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

LORICRIN by GABRG2 expression — BLOOD_Myeloma

Explore this box plot interactively →