GABRE

Across TCGA pan-cancer cohorts, GABRE Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GABRE data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GABRE Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GABRE expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and KIRC are the cancer types where GABRE Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.231	0.746	<.001	62	view →
UCEC	DFS	Median	III,IV	1.000	0.528	.014	18	view →
KIRC	OS	Median	All	0.127	0.874	<.001	12	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
STAD	OS	Median	III,IV	0.169	0.641	.001	6	view →
GBM	OS	Median	All	0.109	0.415	.032	3	view →
SKCM	OS	Median	IV	0.133	0.621	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GABRE–HNSC (OS)

Open the HNSC breakdown →