GABRE

Across TCGA patient cohorts, GABRE mutation is significantly associated with the RNA expression of many other genes, with 3,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRE-associated genes across cancer lineages are RNA5SP112, VPS29, and MRPL34. Each is linked with GABRE in more than 2 cancer types. Because this analysis shows association rather than direction, both GABRE-to-partner and partner-to-GABRE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP112 grouped by GABRE-low versus GABRE-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRE→partner) and Y-score (partner→GABRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP112 →	+0.225	+3.105	.002	.009	3	3
UCEC	VPS29 →	+0.340	+2.217	.001	<.001	3	3
UCEC	MRPL34 →	+0.352	+2.276	.002	<.001	3	3
UCEC	COPS3 →	+0.535	+1.947	<.001	<.001	3	3
HNSC	RNU6-17P →	+0.167	+4.608	<.001	.005	3	3
LUSC	RNA5SP421 →	+1.032	+6.023	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,136 associations by consensus.

RNA5SP112 by GABRE expression — STAD

Explore this box plot interactively →