GABRE

Across TCGA cell cohorts, GABRE mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRE-associated genes across cancer lineages are C4orf50, CCER1, and BTNL2. Each is linked with GABRE in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRE-to-partner and partner-to-GABRE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by GABRE-low versus GABRE-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRE→partner) and Y-score (partner→GABRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C4orf50 →	+0.022	+3.684	<.001	.006	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	BTNL2 →	+0.109	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR11A1 →	+0.039	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PNMA6F →	+0.006	+5.415	<.001	.004	3	1
BLOOD_Lymphoma	TFAP2D →	+0.061	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C4orf50 by GABRE expression — SKIN

Explore this box plot interactively →