Across TCGA patient cohorts, GABRD mutation is significantly associated with the RNA expression of many other genes, with 1,520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRD-associated genes across cancer lineages are CPLX3, C1QBPP1, and RNA5SP198. Each is linked with GABRD in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRD-to-partner and partner-to-GABRD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRD→partner) and Y-score (partner→GABRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CPLX3 →	+0.010	+4.342	<.001	.007	3	2
CESC	C1QBPP1 →	+0.023	+4.837	<.001	.003	3	2
CESC	RNA5SP198 →	+0.198	+4.144	<.001	.009	3	2
UCEC	SAP30 →	+0.613	+2.523	.001	.001	3	2
UCEC	SYAP1 →	+0.435	+3.600	.005	.001	3	2
UCEC	LCP2 →	+0.708	+4.258	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,520 associations by consensus.

Exploration

GABRD survival (RNA) · tumor vs normal (RNA) · all GABRD data types