Across TCGA patient cohorts, GABRD mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRD-associated genes across cancer lineages are MSH2, PKC-delta_pS664, and 14-3-3_beta. Each is linked with GABRD in more than 2 cancer types. Because this analysis shows association rather than direction, both GABRD-to-partner and partner-to-GABRD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRD→partner) and Y-score (partner→GABRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.383	-3.143	<.001	.018	3	2
UCEC	PKC-delta_pS664 →	-0.161	-3.312	.002	.010	2	3
UCEC	14-3-3_beta →	-0.120	-2.295	.008	.033	3	1
UCEC	eEF2 →	+0.531	+3.321	<.001	.009	3	1
UCEC	EGFR_pY1068 →	-0.339	-3.169	.002	.018	3	1
UCEC	eIF4E →	+0.204	+3.013	.031	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

GABRD survival (RNA) · tumor vs normal (RNA) · all GABRD data types