Across TCGA cell cohorts, GABRD mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRD-associated genes across cancer lineages are RAX, FSHB, and UBQLN3. Each is linked with GABRD in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRD-to-partner and partner-to-GABRD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRD→partner) and Y-score (partner→GABRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAX →	+0.532	+4.705	<.001	.003	3	1
LUNG_SCLC	FSHB →	+0.012	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	UBQLN3 →	+0.011	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR52E4 →	+0.102	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.365	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR6V1 →	+0.021	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

GABRD survival (RNA) · tumor vs normal (RNA) · all GABRD data types