GABRB3

Across TCGA patient cohorts, GABRB3 mutation is significantly associated with the RNA expression of many other genes, with 6,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRB3-associated genes across cancer lineages are NUDCD2, PBK, and NCAPG. Each is linked with GABRB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GABRB3-to-partner and partner-to-GABRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUDCD2 grouped by GABRB3-low versus GABRB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB3→partner) and Y-score (partner→GABRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUDCD2 →	+0.460	+2.499	<.001	<.001	3	5
LUAD	PBK →	+0.880	+2.247	.001	.002	3	5
UCEC	NCAPG →	+0.685	+1.513	<.001	<.001	3	5
UCEC	MDH1 →	+0.270	+2.323	.008	<.001	3	5
LUSC	POC1A →	+0.449	+2.471	<.001	<.001	3	5
SKCM	COMMD8 →	+0.505	+1.983	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,350 associations by consensus.

NUDCD2 by GABRB3 expression — UCEC

Explore this box plot interactively →