GABRB3

Across TCGA cell cohorts, GABRB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,119 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GABRB3-associated GO terms across cancer lineages are Cellular response to histamine, Extrasynaptic signaling via GABA, and Gamma-aminobutyric acid signaling pathway. Each is linked with GABRB3 in more than 15 cancer types. Because this analysis shows association rather than direction, both GABRB3-to-partner and partner-to-GABRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to histamine grouped by GABRB3-low versus GABRB3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB3→partner) and Y-score (partner→GABRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to histamine →	-0.257	-2.195	.006	<.001	2	16
BONE	Extrasynaptic signaling via GABA →	+1.412	+3.179	.002	<.001	3	15
OVARY	Gamma-aminobutyric acid signaling pathway →	-0.237	-1.082	<.001	.004	3	12
BREAST	Response to histamine →	-0.220	-1.176	.001	.001	3	8
LUNG_SCLC	Inhibitory postsynaptic potential →	+1.532	+2.924	<.001	<.001	3	7
SKIN	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.042	-1.366	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,119 associations by consensus.

Cellular response to histamine by GABRB3 expression — BONE

Explore this box plot interactively →