GABRB3

Across TCGA cell cohorts, GABRB3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GABRB3-associated genes across cancer lineages are NPFFR1, NDP, and PRND. Each is linked with GABRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRB3-to-partner and partner-to-GABRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPFFR1 grouped by GABRB3-low versus GABRB3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB3→partner) and Y-score (partner→GABRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NPFFR1 →	+0.011	+3.906	<.001	.009	3	2
BLOOD_Leukemia	NDP →	+0.028	+3.855	.005	.007	3	2
BLOOD_Myeloma	PRND →	+0.049	+3.906	.003	.009	3	1
BLOOD_Myeloma	ZNF804B →	+0.026	+3.906	<.001	.009	3	1
BLOOD_Myeloma	OR11H2 →	+0.047	+3.906	<.001	.009	3	1
LUNG_SCLC	RBMY1F →	+0.626	+4.058	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

NPFFR1 by GABRB3 expression — BLOOD_Myeloma

Explore this box plot interactively →