GABRB3

Across TCGA cell cohorts, GABRB3 mutation is significantly associated with the mutation status of many other genes, with 3,461 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GABRB3-associated genes across cancer lineages are RTN1, PYGB, and ATG9A. Each is linked with GABRB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both GABRB3-to-partner and partner-to-GABRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTN1 grouped by GABRB3-low versus GABRB3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB3→partner) and Y-score (partner→GABRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RTN1 →	+4.954	+4.392	.008	.008	1	6
SKIN	PYGB →	+3.357	+3.532	.005	.005	1	5
BLOOD_Leukemia	ATG9A →	+4.635	+4.145	.001	.001	1	5
BLOOD_Leukemia	GRIN2D →	+4.050	+4.260	<.001	<.001	1	4
LUNG_NSCLC_LUAD	KCNH2 →	+2.981	+3.266	.009	.009	1	4
LARGE_INTESTINE	ATP8B4 →	+2.152	+2.787	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,461 associations by consensus.

RTN1 by GABRB3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →